ea0086p328 | Metabolism, Obesity and Diabetes | SFEBES2022
Afees Olanrewaju John
, Olufunmilola Ekundayo Ifeoluwa
, Oluwaseyi Adeniji Kehinde
, Igbo Enya Joseph
, Arietarhire Leviticus
, Soremekun Oladimeji
, Ogunbiyi Olubunmi
, Bamidele Richard
, Taiye Adelodun Stephen
, Yinka Olatunji Sunday
, Afolabi Toluwanimi
, Zabdiel Abijo Ayodeji
, Owolabi Joshua
Cognitive impairment and neurodegeneration are a few hallmarks of brain insulin resistance, a core feature of Type 2 diabetes mellitus (T2DM). Using a Wistar rat model of a high-fat diet and streptozotocin-induced T2DM, we aimed to determine the potential of Vernonia amygdalina (VA) as a possible treatment for the accompanied neurodegenerative effects of this condition on hippocampal structure and function. T2DM adult rats were prepared by a combination of a high-fat diet and ...